Dimethyl Sulfoxide → HCID 18977180, 화합물

HRID 2393736노트

반응식

HRID 2393736 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH2:13][CH2:14][C:15](=[O:18])[NH:16][N:17]=2)=[CH:8][CH:7]=1.[BrH:19].C(O)(=O)C.CS(C)=O.C(OC(C)C)(C)C>C(O)(=O)C>[BrH:19].[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[NH:16][N:17]=2)=[CH:10][CH:11]=1

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 7914Diisopropyl EtherHCID 18977184HCID 18977184, 화합물HCID 21893785Acetic Acid Mixture with Hydrobromic Acid

생성물 1

HCID 18977180HCID 18977180, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

In 200 ml of acetic acid was suspended 15.00 g of 6-[4-(4-aminobutyl)phenyl]-4,5-dihydropyridazin-3(2H)-one. To the suspension were added 100 ml of a 25% hydrogen bromide-acetic acid solution and then 5.35 g of dimethylsulfoxide, and the mixture was stirred at room temperature for 4.5 hours. 400 ml of isopropyl ether was added to the reaction mixture, and precipitated crystal was collected by filtration and recrystallized from methanol to obtain 18.94 g of 6-[4-(4-aminobutyl)phenyl]pyridazin-3(2H)-one hydrobromide.

후처리

  1. customprecipitated crystal
  2. filtrationwas collected by filtration
  3. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-2261f0e9b39b48fbb6b01f54c9e9a307
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05808065

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