Lithium hydroxide, monohydrate → 3-Methoxyindole-6-carboxylic acid
반응식
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([O:15]C)=[O:14])[CH:11]=2)[C:6]([O:17][CH3:18])=[CH:5]1)(=O)C.O.[OH-].[Li+]>C1COCC1.O>[CH3:18][O:17][C:6]1[C:7]2[C:12](=[CH:11][C:10]([C:13]([OH:15])=[O:14])=[CH:9][CH:8]=2)[NH:4][CH:5]=1참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
To a solution of methyl 1-acetyl-3-methoxyindole-6-carboxylate (74 mg, 0.3 mmol) in THF (10 ml) and water (2 ml) was added lithium hydroxide hydrate (63 mg, 1.5 mmol). The reaction mixture was warmed to 50° C. and stirred for 3 h. The THF was removed under reduced pressure and the pH of the aqueous phase adjusted to 3. Extraction of the aqueous layer with ethyl acetate, drying and concentration gave the acid (50 mg, 87%);
후처리
- customThe THF was removed under reduced pressure
- extractionExtraction of the aqueous layer with ethyl acetate
- customdrying
- concentrationconcentration
출처 및 근거
- ORD 기록
- ord-a114a88948d74f7f916aad27722aebe7
- 출처 데이터셋
- uspto-grants-2005_02
- 특허 번호
- US06855715B1
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