Hydrochloric Acid → 5-Cyanopentanoic acid

HRID 2395211노트

반응식

HRID 2395211 반응식
[NH4+].[C:2]([CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O-:10])=[O:9])#[N:3].Cl>>[C:2]([CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9])#[N:3]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 19044055HCID 19044055, 화합물

생성물 1

HCID 1999265-Cyanopentanoic acid수율 95%

실험 절차

A 200-mL portion of the filtrate of the product mixture described above, containing the 5-cyanopentanoic acid ammonium salt (1.13M), was adjusted to pH 2.5 with 6N HCl, then saturated with sodium chloride and extracted with 4×200 mL of ethyl ether. The combined ether extracts were dried over magnesium sulfate, filtered, and the solvent removed by rotary evaporation at reduced pressure. Remaining ether was removed by stirring the colorless liquid at room temperature under high vacuum (60 millitorr) for 5 h to yield 27.32 g (95% isolated yield) of 5-cyanopentanoic acid. The 5-cyanopentanoic acid was then distilled under vacuum (75 millitorr) at 110°-112° C. without decomposition.

후처리

  1. extractionsaturated with sodium chloride and extracted with 4×200 mL of ethyl ether
  2. dry with materialThe combined ether extracts were dried over magnesium sulfate
  3. filtrationfiltered
  4. customthe solvent removed by rotary evaporation at reduced pressure
  5. customRemaining ether was removed

출처 및 근거

ORD 기록
ord-b4d267818c404872879b09d41474329c
출처 데이터셋
uspto-grants-1998_09
특허 번호
US05814508

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