Sulfuric Acid → 3-(Acetyloxy)-4-methylbenzoic acid

HRID 23953

반응식

HRID 23953 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[C:17](OC(=O)C)(=[O:19])[CH3:18]>O>[C:17]([O:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=[O:6])(=[O:19])[CH3:18]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 685123-Hydroxy-4-methylbenzoic acid

생성물 1

HCID 225699983-(Acetyloxy)-4-methylbenzoic acid수율 30%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

A solution of 3-hydroxy-4-methylbenzoic acid (3.0 g, 19.7 mmol) in acetic anhydride (5.6 mL) was treated with sulfuric acid (0.03 mL), heated to 70° C., cooled and diluted with water. The resulting solid was collected by filtration yielding 1.14 g (30%) of the title compound, which was used without further purification.

후처리

  1. temperaturecooled
  2. filtrationThe resulting solid was collected by filtration

출처 및 근거

ORD 기록
ord-7908a31fbbb64d2282804f5d3fcaa166
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855715B1

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