1,1-Dibromoethane → 1,2-Diphenyl-1-[4-(2-bromoethoxy)phenyl]-1-buten-4-ol

HRID 2396134노트

반응식

HRID 2396134 반응식
[C:1]1(/[C:7](/[C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=2)=[C:8](/[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)\[CH2:9][CH2:10][OH:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:25][CH:26](Br)[CH3:27].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[C:1]1([C:7]([C:18]2[CH:19]=[CH:20][C:21]([O:24][CH2:27][CH2:26][Br:25])=[CH:22][CH:23]=2)=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:9][CH2:10][OH:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 112011,1-DibromoethaneHCID 11430Potassium CarbonateHCID 13298065Z-4-(4-hydroxy-1,2-diphenyl-but-1-enyl)-phenol

생성물 1

HCID 544646161,2-Diphenyl-1-[4-(2-bromoethoxy)phenyl]-1-buten-4-ol

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A mixture containing 31,6 g of (Z)-1,2-diphenyl-1-(4-hydroxyphenyl)-1-buten-4-ol, 93,9 g of dibromoethane, 20,7 g of anhydrous potassium carbonate and 250 ml of methyl ethyl ketone is refluxed for 24 h. The inorganic salts are removed by filtration followed by evaporating the solvent and recrystallizing frommethanol. The yield is 17,3 g (41%) and m.p. 133°-7° C.

후처리

  1. temperatureis refluxed for 24 h
  2. customThe inorganic salts are removed by filtration
  3. customby evaporating the solvent
  4. customrecrystallizing frommethanol

출처 및 근거

ORD 기록
ord-ca650d11455a4e3f8e8c46b6eea5dec0
출처 데이터셋
uspto-grants-1996_02
특허 번호
US05491173

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