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Tetrahydrofuran → 4,6-Dichloro-3-[(2-oxo-2-phenylethyl)amino]-1H-indole-2-carboxylic acid

HRID 2396345
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HRID 2396345 반응식
[CH2:1]([NH:10][C:11]1[C:19]2[C:14](=[CH:15][C:16]([Cl:21])=[CH:17][C:18]=2[Cl:20])[NH:13][C:12]=1[C:22]([O:24]CC)=[O:23])[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3].O.[OH-].[Li+].O1CCCC1>O.C(OCC)(=O)C>[CH2:1]([NH:10][C:11]1[C:19]2[C:14](=[CH:15][C:16]([Cl:21])=[CH:17][C:18]=2[Cl:20])[NH:13][C:12]=1[C:22]([OH:24])=[O:23])[C:2]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1)=[O:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 8028TetrahydrofuranHCID 168937Lithium hydroxide, monohydrateHCID 21460706HCID 21460706, 화합물

생성물 1

HCID 214606834,6-Dichloro-3-[(2-oxo-2-phenylethyl)amino]-1H-indole-2-carboxylic acid수율 64%

시약·촉매·용매 2

HCID 962Water용매2회
HCID 8857
Ethyl Acetate
용매

실험 절차

Mix 3-[(phenacyl)amino]-2-carbethoxy-4,6-dichloroindole (300 mg, 0.79 mmol), lithium hydroxide monohydrate (2.39 mmol), tetrahydrofuran (2 mL) and water (2 mL). Stir at room temperature overnight. Dilute with water and ethyl acetate. Acidify the aqueous phase and separate the organic phase. Dry (MgSO4), evaporate the solvent in vacuo, and recrystallizethe residue (ethyl acetate/hexane) to give the title compound (175 mg, 64%).

후처리

  1. customseparate the organic phase
  2. dry with materialDry (MgSO4)
  3. customevaporate the solvent in vacuo, and recrystallizethe residue (ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-861d0cc2aee148d78ad61de220dafbdf
출처 데이터셋
uspto-grants-1996_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05491153

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