Triethylamine → benzyl N-pyridin-3-ylcarbamate
반응식
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.C(N(CC)CC)C.Cl[C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17]>ClCCl>[C:16]([NH:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1)([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17]참가 물질
5
실험 절차
To a solution of 3-aminopyridine (10 g, 0.106 mol) and triethyl amine (16.3 mL, 0.117 mol) in dichloromethane (100 mL) at 0° C., was added benzyl chloroformate (15.2 mL, 0.106 mol) slowly. The reaction mixture was stirred overnight and was washed with water, saturated NaHCO3, dried over MgSO4, and evaporated. The residue was purified on a silica gel column to give the product (9.51 g)
후처리
- washwas washed with water, saturated NaHCO3
- dry with materialdried over MgSO4
- customevaporated
- customThe residue was purified on a silica gel column
출처 및 근거
- ORD 기록
- ord-21302e956b554cc7913f7c0fb9fb4cf0
- 출처 데이터셋
- uspto-grants-1996_02
- 특허 번호
- US05492916
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