돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2397003생성일: 2026년 10월 25일

6-Methoxy-9H-purine → (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9(9H)-purinyl]ethyl] oxirane

https://huagongshe.com/reaction/2397003

반응식

참여 물질

역할이름HCID투입량
반응물6-Methoxy-9H-purineHCID 70632—
반응물(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanolHCID 10631861—
반응물(2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-7(7H)-purinyl]ethyl]oxiraneHCID 22859142—
생성물(2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9(9H)-purinyl]ethyl] oxiraneHCID 1865762821.1%

반응 단계

Using (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol (523 mg) and 6-methoxypurine 1/2 hydrate (415 mg), (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-7(7H)purinyl]ethyl]oxirane (205 mg) and (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9(9H)-purinyl]ethyl]oxirane (183 mg) were obtained as a white powder respectively by the same way as in Reference Example 2.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US05495024
출처 데이터셋uspto-grants-1996_02
ORD IDord-cf7180fde80649579b3443b9df903eff
출처 메모uspto-grants-1996_02