Hydrochloric Acid → 6,7-Dimethoxy-N-methyl-1-isochromanmethylamine

반응식

Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[CH:10]([CH2:16][NH2:17])[O:9][CH2:8][CH2:7]2.[CH2:18]=O.Cl>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[CH:10]([CH2:16][NH:17][CH3:18])[O:9][CH2:8][CH2:7]2

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 712Formaldehyde2회

HCID 122258856,7-Dimethoxy-1-isochromanmethylamine hydrochloride

생성물 1

HCID 125300406,7-Dimethoxy-N-methyl-1-isochromanmethylamine

실험 절차

A mixture of 6,7-dimethoxy-1-isochromanmethylamine hydrochloride (6.0 g), described in Example 1, and 37% formaldehyde solution (12 ml) is heated on the steam bath under a reflux condenser for 20 min. A further 6 ml formaldehyde solution is added and heating is continued for 20 min. The solution is evaporated to dryness and the residue is crystallized from isopropanol to give the hydrochloric acid addition salt of the title compound, m.p. 254°-256° C. (dec.).