(Pyridin-4-yl)[3-(trifluoromethyl)phenyl]methanone → ALPHA-[3-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINEMETHANOL

HRID 2397469노트

반응식

HRID 2397469 반응식
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:16]=1)[C:6]([C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)=[O:7].[H][H]>CO.Cl.[Pt]=O>[OH:7][CH:6]([CH:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)[C:5]1[CH:14]=[CH:15][CH:16]=[C:3]([C:2]([F:1])([F:17])[F:18])[CH:4]=1

참가 물질

6

반응물 2

HCID 21438388(Pyridin-4-yl)[3-(trifluoromethyl)phenyl]methanoneHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 11392289ALPHA-[3-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINEMETHANOL

시약·촉매·용매 3

HCID 82844Platinum oxide (PtO)촉매HCID 313Hydrochloric Acid용매HCID 887Methanol용매

실험 절차

A solution of 25.1 g (0.1 mole) of 4-(m-trifluoromethylbenzoyl)pyridine in 150 ml methanol and 10 ml concentrated hydrochloric acid was shaken with one gram of platinum oxide at an initial pressure of fifty psi of hydrogen. The hydrogen uptake was complete in ten hours. The catalyst was filtered off. After removal of the methanol under reduced pressure, the residue was dissolved in water and made basic with sodium hydroxide. Extraction with benzene and concentration of the benzene solution gave crude 4-(alpha-hydroxy-m-trifluoromethylbenzyl)piperidine. Yield 20.2 grams.

후처리

  1. filtrationThe catalyst was filtered off
  2. customAfter removal of the methanol under reduced pressure
  3. dissolutionthe residue was dissolved in water
  4. extractionExtraction with benzene and concentration of the benzene solution

출처 및 근거

ORD 기록
ord-3d4de6eb1dd9463faaabceb87b8da30f
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04021564

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