Ethyl Bromide → 2-(3-Ethoxyphenyl)-4,5-dihydropyrazolo[1,5-a]quinoline

HRID 2398082노트

반응식

HRID 2398082 반응식
[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:20]=[C:11]3[CH2:12][CH2:13][C:14]4[C:19]([N:10]3[N:9]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:5]=[CH:6][CH:7]=1.[Na].[CH2:22](Br)[CH3:23]>C(O)C>[CH2:22]([O:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:20]=[C:11]3[CH2:12][CH2:13][C:14]4[C:19]([N:10]3[N:9]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:5]=[CH:6][CH:7]=1)[CH3:23]

참가 물질

5

반응물 3

HCID 6332Ethyl BromideHCID 3042689Phenol, 3-(4,5-dihydropyrazolo(1,5-a)quinolin-2-yl)-HCID 5360545Sodium

생성물 1

HCID 134125132-(3-Ethoxyphenyl)-4,5-dihydropyrazolo[1,5-a]quinoline

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.62 Grams (0.010 mole) of the compound of Example 10 is added to a solution of 0.23 g. (0.010 mole) of sodium in 40 ml. of absolute ethanol at room temperature, then 2.2 g. (0.020 mole) of ethyl bromide is added dropwise. The resulting solution is refluxed for seven hours and allowed to stand overnight at room temperature. After dilution with 30 ml. of water and subsequent evaporation of the ethanol, a residue is obtained which is crystallized from methanol. Yield 2.29 g. of the title compound, m.p. 99°-100° C.

후처리

  1. customat room temperature
  2. temperatureThe resulting solution is refluxed for seven hours
  3. customof water and subsequent evaporation of the ethanol
  4. customa residue is obtained which
  5. customis crystallized from methanol

출처 및 근거

ORD 기록
ord-5ee4a91051b24501ab41c0447622520e
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04024149

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