반응식
[NH2:1][CH2:2][C:3]1([CH2:9][C:10]([OH:12])=[O:11])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[ClH:13].[CH2:14](O)[CH3:15]>>[NH2:1][CH2:2][C:3]1([CH2:9][C:10]([O:12][CH2:14][CH3:15])=[O:11])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[ClH:13]참가 물질
5
실험 절차
10 g. of the 1-aminomethyl-1-cyclohexane-acetic acid, prepared according to Example 1, are dissolved in 50 ml. anhydrous ethanol and saturated at 0° C. with gaseous hydrogen chloride. The reaction mixture is left to stand overnight at ambient temperature, then evaporated in a vacuum and the residue recrystallised from ethanol/ether. Ethyl 1-aminomethyl-1-cyclohexane-acetate is obtained in the form of its hydrochloride; m.p. 161°-163° C.
후처리
- dissolutionare dissolved in 50 ml
- customsaturated at 0° C.
- waitThe reaction mixture is left
- customevaporated in a vacuum
- customthe residue recrystallised from ethanol/ether
출처 및 근거
- ORD 기록
- ord-5b486aab7e8f4d858162b956a36109a8
- 출처 데이터셋
- uspto-grants-1977_05
- 특허 번호
- US04024175
연결된 노트
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