Acetone → 1-(4-chlorophenyl)-2-phenoxyethanone

HRID 2398473노트

반응식

HRID 2398473 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4].[C:12]1([OH:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+].CC(C)=O>O>[O:18]([CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

6

반응물 4

HCID 180AcetoneHCID 996PhenolHCID 11430Potassium CarbonateHCID 68303p-Chlorophenacyl bromide

생성물 1

HCID 14715261-(4-chlorophenyl)-2-phenoxyethanone

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 23.3 g. (0.1 mol.) of α-bromo-p-chloroacetophenone, 10.0 g. (0.1 mol.) of phenol and 14.5 g. (0.1 mol.) of potassium carbonate in 65 ml. of dry acetone is refluxed for 12 hours. The reaction mixture is cooled, poured into 500 ml. of water and the precipitate formed is collected by filtration and recrystallized from ethanol to give α-phenoxy-p-chloroacetophenone.

후처리

  1. additionA mixture of 23.3 g
  2. temperatureThe reaction mixture is cooled
  3. additionpoured into 500 ml
  4. filtrationis collected by filtration
  5. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-7e1122842d8347b788d818eed2b75589
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04024273

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