Thiosemicarbazide → 1-(1-Methyl-5-nitro-2-imidazolecarbonyl)-3-thiosemicarbazide
반응식
[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10](Cl)=[O:11].[NH2:13][NH:14][C:15]([NH2:17])=[S:16]>O1CCCC1>[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10]([NH:13][NH:14][C:15]([NH2:17])=[S:16])=[O:11]참가 물질
4
실험 절차
To 1-methyl-5-nitro-2-imidazolecarboxylic acid chloride (1.1 g.) in 25 ml. of dry tetrahydrofuran is added 0.55 g. powdered thiosemicarbazide and the mixture is stirred at room temperature for 24 hours. The reaction mixture is evaporated to dryness and water is added. The solution is made basic with sodium hydroxide and the solid is filtered, washed with water and dried affording 1-(1-methyl-5-nitro-2-imidazolecarbonyl)-3-thiosemicarbazide.
후처리
- customThe reaction mixture is evaporated to dryness and water
- additionis added
- filtrationthe solid is filtered
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-9666a97a95734b01b73d32dae1d697a8
- 출처 데이터셋
- uspto-grants-1977_05
- 특허 번호
- US04026903
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