Pyridine → HCID 18973686, 화합물

HRID 2399413노트

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HRID 2399413 반응식
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])[CH2:9]O)[CH2:3][CH2:2]1.N1C=CC=CC=1.S(Cl)([Cl:26])=O>C(Cl)(Cl)Cl>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])[CH2:9][Cl:26])[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 54527366HCID 54527366, 화합물

생성물 1

HCID 18973686HCID 18973686, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A solution of crude 3-cyclopropylmethoxy-4-difluoromethoxybenzyl alcohol (24.4 g) and pyridine (9.8 mL, 120 mmol) in chloroform (150 mL) under an argon atmosphere was treated with thionyl chloride (8.0 mL, 110 mmol) and the mixture was heated at reflux for 1 h. The solvent was removed, ether was added and the precipitate was removed by filtration. The filtrate was concentrated to a pale yellow oil (26 g).

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 1 h
  3. customThe solvent was removed
  4. additionether was added
  5. customthe precipitate was removed by filtration
  6. concentrationThe filtrate was concentrated to a pale yellow oil (26 g)

출처 및 근거

ORD 기록
ord-dc50575213254386a18d973dcacb78df
출처 데이터셋
uspto-grants-1995_09
특허 번호
US05449686

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