Hydrochloric Acid → 4-Ethylaminomethyl-4-hydroxypiperidine dihydrochloride

HRID 2400077노트

반응식

HRID 2400077 반응식
[CH2:1]([NH:3][CH2:4][C:5]1([OH:16])[CH2:10][CH2:9][N:8](C(OCC)=O)[CH2:7][CH2:6]1)[CH3:2].[ClH:17]>>[ClH:17].[ClH:17].[CH2:1]([NH:3][CH2:4][C:5]1([OH:16])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[CH3:2]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 19382186HCID 19382186, 화합물

생성물 1

HCID 193821764-Ethylaminomethyl-4-hydroxypiperidine dihydrochloride

실험 절차

4.6 g (20 mmol) of ethyl 4-ethylaminomethyl-4-hydroxypiperidine-1-carboxylate are heated overnight under reflux with 35 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are triturated with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

후처리

  1. concentrationThe product is concentrated
  2. customthe crystals are triturated with acetone
  3. filtrationfiltered off with suction
  4. dry with materialdried in a vacuum desiccator over P4O10

출처 및 근거

ORD 기록
ord-c0d7121fd6074758bc75edd21881b338
출처 데이터셋
uspto-grants-1995_09
특허 번호
US05453422

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