Iodine → 6-ethyl-5-iodo-2-phenyl-4(3H)-pyrimidinone

HRID 2400101

반응식

HRID 2400101 반응식
[CH2:1]([C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[NH:6][C:5](=[O:15])[CH:4]=1)[CH3:2].[OH-].[Na+].[I:18]I>O>[CH2:1]([C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[NH:6][C:5](=[O:15])[C:4]=1[I:18])[CH3:2]

참가 물질

5

반응물 3

HCID 807IodineHCID 14798Sodium HydroxideHCID 1356298226-Ethyl-2-phenylpyrimidin-4(1H)-one

생성물 1

HCID 1358375326-ethyl-5-iodo-2-phenyl-4(3H)-pyrimidinone수율 94.5%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

A mixture of 8.18 g (40.9 mmol) of 6-ethyl-2-phenyl-4(3H)-pyrimidinone, 1.68 g (42.0 mmol) of sodium hydroxide, 10.42 g (41.0 mmol) of iodine and 50 mL of water was heated at 50° C. for 4 h. The mixture was cooled and filtered. The white solid collected was dried in a vacuum oven to leave 12.60 g (75%) of 6-ethyl-5-iodo-2-phenyl-4(3H)-pyrimidinone. 1H-NMR (d6-DMSO)δ1.25(3H,t), 2.85(2H,q), 7.50(3H,m), 8.15(2H,m).

후처리

  1. temperatureThe mixture was cooled
  2. filtrationfiltered
  3. customThe white solid collected
  4. customwas dried in a vacuum oven

출처 및 근거

ORD 기록
ord-e3a97a1d6cae4d4297aa9e59f9540306
출처 데이터셋
uspto-grants-1995_09
특허 번호
US05453414

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