홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Diisopropylethylamine → 6-Methoxy-8-morpholin-4-ylmethyl-2-oxo-2H-chromene-3-carboxylic acid (3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide

HRID 240015
노트
인쇄 미리보기

반응식

HRID 240015 반응식
CCN(C(C)C)C(C)C.[N:10]1([CH2:16][C:17]2[CH:18]=[C:19]([O:31][CH3:32])[CH:20]=[C:21]3[C:26]=2[O:25][C:24](=[O:27])[C:23]([C:28](O)=[O:29])=[CH:22]3)[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[N:57]1[C:58]([C:66]2[CH:67]=[C:68]([NH2:72])[CH:69]=[CH:70][CH:71]=2)=[CH:59][N:60]2[CH:65]=[CH:64][CH:63]=[CH:62][C:61]=12>CN(C)C=O>[N:57]1[C:58]([C:66]2[CH:67]=[C:68]([NH:72][C:28]([C:23]3[C:24](=[O:27])[O:25][C:26]4[C:21]([CH:22]=3)=[CH:20][C:19]([O:31][CH3:32])=[CH:18][C:17]=4[CH2:16][N:10]3[CH2:15][CH2:14][O:13][CH2:12][CH2:11]3)=[O:29])[CH:69]=[CH:70][CH:71]=2)=[CH:59][N:60]2[CH:65]=[CH:64][CH:63]=[CH:62][C:61]=12
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 81531DiisopropylethylamineHCID 6970213-(Imidazo(1,2-a)pyridin-2-yl)anilineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 866503618-(4-Morpholinylmethyl)-3-carboxy-6-methoxy-coumarin

생성물 1

HCID 86650360
6-Methoxy-8-morpholin-4-ylmethyl-2-oxo-2H-chromene-3-carboxylic acid (3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide
수율 59%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

DIEA (0.030 mL, 0.17 mmol) was added to 8-(4-morpholinylmethyl)-3-carboxy-6-methoxy-coumarin (0.050 g, 0.16 mmol) and HATU (0.065 g, 0.17 mmol) in 1 mL of dimethylformamide (DMF) with constant stirring at room temperature until a clear solution resulted. Subsequently, 3-imidazo[1,2-a]pyridin-2-yl-phenylamine (0.033 g, 0.16 mmol) was added and allowed to react overnight, when a yellow solid precipitated out of solution. The precipitate was filtered and dried under suction and then in vacuo to give 0.047 g of 1541D in a 59% yield: LCMS (ESI) m/z 511 (MH+).

후처리

  1. customresulted
  2. customto react overnight
  3. customwhen a yellow solid precipitated out of solution
  4. filtrationThe precipitate was filtered
  5. customdried under suction

출처 및 근거

ORD 기록
ord-f283fc0316b440feae461ad363ea6281
출처 데이터셋
uspto-grants-2014_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08642788B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트