Methyl iodide → Methyl 4-(acetylamino)-3-nitrobenzoate

HRID 2400187

반응식

HRID 2400187 반응식
[C:1]([NH:4][C:5]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]=1O)(=[O:3])[CH3:2].[CH:18](N(C(C)C)CC)(C)C.CI>CN(C=O)C>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([C:9]([O:11][CH3:18])=[O:10])=[CH:12][C:13]=1[N+:14]([O-:16])=[O:15])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 81531DiisopropylethylamineHCID 33646654-(Acetylamino)-3-hydroxy-5-nitrobenzoic acid

생성물 1

HCID 236856Methyl 4-(acetylamino)-3-nitrobenzoate수율 94.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Compound 107 (1.50 g, 6.69 mmol) was dissolved in DMF (25 mL), and diisopropylethylamine (16.0, 92.7 mmol) and MeI (2.3 mL, 39 mmol) were added. The solid which formed was filtered and the filtrate was concentrated to dryness on a rotary evaporator to provide 15 (1.50 g, 94.3%) as a yellow solid: mp 123°-124° C. (ethanol). The literature (Appleton et al., 1970) reports mp 127° C.

후처리

  1. customThe solid which formed
  2. filtrationwas filtered
  3. concentrationthe filtrate was concentrated to dryness on a rotary evaporator

출처 및 근거

ORD 기록
ord-0e3cef2f91ae468d9e3d532552d23f8b
출처 데이터셋
uspto-grants-1995_09
특허 번호
US05453533

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