2,2-Dimethyl-1,3-dioxane-4,6-dione → 7,8-Dimethoxy-3-carboxy-coumarin
반응식
[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[C:5]([CH:6]=O)[C:4]=1[OH:13].CC1(C)O[C:20](=[O:21])[CH2:19][C:17](=[O:18])[O:16]1>O>[CH3:12][O:11][C:10]1[C:3]([O:2][CH3:1])=[C:4]2[C:5]([CH:6]=[C:19]([C:17]([OH:18])=[O:16])[C:20](=[O:21])[O:13]2)=[CH:8][CH:9]=1참가 물질
4
반응 조건
- 온도
- 75 °C
실험 절차
3,4-dimethoxy-salicylaldehyde (252.8 mg, 1.39 mmol) and Meldrum's acid (200 mg, 1.39 mmol) were combined in H2O (2 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 271.0 mg of 7,8-dimethoxy-3-carboxy-coumarin in an 78% yield.
후처리
- temperatureAfter cooling to room temperature
- filtrationthe precipitate was filtered
- customdried at suction
출처 및 근거
- ORD 기록
- ord-1c1d151adb9e46e2b8b59c4bd1951d8d
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08642788B2
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