2-(Benzylamino)pyridine → HCID 11960665, 화합물

HRID 2401068

반응식

HRID 2401068 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:17]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24]Cl)=[CH:20][CH:19]=2)=[N:16][CH:15]=[CH:14][N:13]=1)(=[O:10])=[O:9].[CH2:26]([NH:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:26]([N:33]([CH2:24][C:21]1[CH:20]=[CH:19][C:18]([C:17]2[C:12]([NH:11][S:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])(=[O:10])=[O:9])=[N:13][CH:14]=[CH:15][N:16]=2)=[CH:23][CH:22]=1)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=1)[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

참가 물질

3

반응물 2

HCID 233622-(Benzylamino)pyridineHCID 57444254HCID 57444254, 화합물2회

생성물 1

HCID 11960665HCID 11960665, 화합물수율 35%

실험 절차

Following the general method as outlined in Example 1 (Method B), starting from N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(chloro) benzenesulfonamide (Intermediate 8), and 2-benzylaminopyridine, the title compound was isolated as a yellow solid in 35% yield (94% purity by HPLC).

출처 및 근거

ORD 기록
ord-6cf549fa2c954c6c921392dc272dfe8c
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08796280B2

연결된 노트

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