Hydrochloric Acid → 1-(6-Chloropyrimidin-4-yl)ethan-1-one

HRID 2401189노트

반응식

HRID 2401189 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([O:10]CC)=[CH2:9])[N:5]=[CH:4][N:3]=1.Cl>CC(C)=O>[Cl:1][C:2]1[N:3]=[CH:4][N:5]=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 865947284-Chloro-6-(1-ethoxyvinyl)pyrimidine2회

생성물 1

HCID 722142471-(6-Chloropyrimidin-4-yl)ethan-1-one수율 76.6%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

4-Chloro-6-[1-(ethyloxy)ethenyl]pyrimidine (Intermediate 17, 3.54 g, 19.17 mmol) was dissolved in acetone (177 mL), treated with 2M aqueous hydrochloric acid solution (28.8 mL, 57.5 mmol) and the resulting mixture was stirred at room temperature for 18 hours. The solvent was removed under reduced pressure. The residue was neutralised with aqueous saturated sodium bicarbonate solution and extracted with ethyl acetate (×2). The ethyl acetate layers were combined, dried under magnesium sulfate and evaporated under reduced pressure to give the title compound as a white solid (2.30 g);

후처리

  1. customThe solvent was removed under reduced pressure
  2. extractionextracted with ethyl acetate (×2)
  3. customdried under magnesium sulfate
  4. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-a7553d8829d3406b8e834eeafe3f7f94
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08796283B2

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