Sodium borohydride → 1-(6-Chloropyrimidin-4-yl)ethanol

HRID 2401190노트

반응식

HRID 2401190 반응식
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8](=[O:10])[CH3:9])[CH:3]=1.[BH4-].[Na+]>C(O)C>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([CH:8]([OH:10])[CH3:9])[CH:3]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 722142471-(6-Chloropyrimidin-4-yl)ethan-1-one2회

생성물 1

HCID 838541011-(6-Chloropyrimidin-4-yl)ethanol수율 79.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1-(6-Chloro-4-pyrimidinyl)ethanone (Intermediate 18A, 1.0 g, 6.39 mmol) was dissolved in ethanol (21 mL), treated with sodium borohydride (0.242 g, 6.39 mmol) and the resulting mixture was stirred at room temperature under argon for 2 hours. The solvent was removed under reduced pressure and the residue was diluted with water and extracted with ethyl acetate (×3). The ethyl acetate layers were combined, dried under magnesium sulfate and evaporated under reduced pressure to give the title compound as a yellow oil (808 mg);

후처리

  1. customThe solvent was removed under reduced pressure
  2. additionthe residue was diluted with water
  3. extractionextracted with ethyl acetate (×3)
  4. customdried under magnesium sulfate
  5. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-e2acdec75d9640a7ac4fac48b35ea0e7
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08796283B2

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