Pyridine → Carbamic acid, [6-(trifluoromethyl)-3-pyridinyl]-, phenyl ester

HRID 2401258노트

반응식

HRID 2401258 반응식
N1C=CC=CC=1.[F:7][C:8]([F:17])([F:16])[C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][N:10]=1.Cl[C:19]([O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:20]>C(Cl)(Cl)Cl>[C:22]1([O:21][C:19](=[O:20])[NH:15][C:12]2[CH:11]=[N:10][C:9]([C:8]([F:7])([F:16])[F:17])=[CH:14][CH:13]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 15891Phenyl chloroformateHCID 27377445-Amino-2-(trifluoromethyl)pyridine

생성물 1

HCID 11173582Carbamic acid, [6-(trifluoromethyl)-3-pyridinyl]-, phenyl ester

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Pyridine (2.9 mL) was added to a solution of 2-trifluoromethyl-5-aminopyridine (1.95 g) in chloroform (15 mL), the mixture was cooled in ice, and phenyl chloroformate (1.8 mL) was added thereto. The resulting mixture was stirred at room temperature overnight, and the reaction mixture was concentrated under reduced pressure. The residue was washed with isopropyl ether to afford phenyl[6-(trifluoromethyl)pyridin-3-yl]carbamate (2.16 g).

후처리

  1. temperaturethe mixture was cooled in ice
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. washThe residue was washed with isopropyl ether

출처 및 근거

ORD 기록
ord-5d1832adacc84cc5a9b528ac0e14cb03
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08796272B2

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