Water → (S)-4-Isopropylimidazolidin-2-one

HRID 2401264노트

반응식

HRID 2401264 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][CH:8]([C@@H:10]1[NH:14][C:13](=[O:15])[NH:12][C:11]1=O)[CH3:9].O.[OH-].[Na+]>C(OCC)C.C(O)C.C1COCC1>[CH3:7][CH:8]([C@H:10]1[CH2:11][NH:12][C:13](=[O:15])[NH:14]1)[CH3:9]

참가 물질

8

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 853633AC1LgxvoHCID 21226445Aluminium lithium hydride

생성물 1

HCID 24808374(S)-4-Isopropylimidazolidin-2-one수율 32.9%

시약·촉매·용매 3

HCID 702Ethanol용매HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

To a suspension of lithium aluminum hydride (290 mg) in diethyl ether (20 mL) was added (5S)-5-(propan-2-yl)imidazolidine-2,4-dione (540 mg) while cooling in ice, and the mixture was stirred at room temperature overnight. After cooling in ice, water (1 mL), 4M aqueous sodium hydroxide solution (1 mL), THF (15 mL) and ethanol (2 mL) were added thereto, and the resulting mixture was stirred at room temperature for 10 min. After filtration through Celite (registered trademark), the filtrate was concentrated under reduced pressure to afford (4S)-4-(propan-2-yl)imidazolidin-2-one (160 mg).

후처리

  1. temperaturewhile cooling in ice
  2. temperatureAfter cooling in ice
  3. stirringthe resulting mixture was stirred at room temperature for 10 min
  4. filtrationAfter filtration through Celite (registered trademark)
  5. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a0f901b1a0fb4c018c91ba77d1b9eaeb
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08796272B2

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