Phosphorus oxychloride → 2-Chloro-4-phenylquinazoline

HRID 2402490노트

반응식

[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9](=O)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)([Cl:20])=O>>[Cl:20][C:9]1[N:8]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 634302(1H)-Quinazolinone, 4-phenyl-

생성물 1

HCID 31235822-Chloro-4-phenylquinazoline

반응 조건

온도: 105 °C

실험 절차

A flask was charged with 4-phenylquinazolin-2(1H)-one (110 g, 0.51 mol) and phosphorus oxychloride (300 mL), and the mixture was stirred at 105° C. for 30 min. The reaction mixture was cooled to rt and slowly poured over an ice/water mixture. The solid was collected by filtration, washed with water (50 mL) and dried under reduced pressure. The product, 2-chloro-4-phenylquinazoline, was isolated as an off-white solid (110 g, 91%).

후처리

temperatureThe reaction mixture was cooled to rt
filtrationThe solid was collected by filtration
washwashed with water (50 mL)
customdried under reduced pressure

출처 및 근거

ORD 기록: ord-be8404ec798a4500ac1455fb687fa3b6
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08796294B2

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