Potassium Carbonate → 2-Bromo-1-(4-fluoro-3-methylphenyl)ethanone
반응식
[Br:1][CH2:2][C:3]([O:5]C)=O.[F:7][C:8]1[CH:13]=[CH:12][C:11](C2N=C(C3C=CC=CC=3)NC=2)=[CH:10][C:9]=1[CH3:25].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:1][CH2:2][C:3]([C:11]1[CH:12]=[CH:13][C:8]([F:7])=[C:9]([CH3:25])[CH:10]=1)=[O:5]참가 물질
5
실험 절차
0.41 mL methyl bromoacetate was added to 1 g 4-(4-fluoro-3-methyl-phenyl)-2-phenyl-1H-imidazole and 1.66 g potassium carbonate in 10 mL DMF. The reaction was stirred 3 h at RT. Then 0.41 mL methyl bromoacetate was added and the reaction was stirred overnight at RT. The reaction mixture was added to ice water and extracted with DCM. The organic layer was dried and evaporated to give 1 g desired product. Rt: 0.94 min (method A), (M+H)+: 325
후처리
- stirringthe reaction was stirred overnight at RT
- extractionextracted with DCM
- customThe organic layer was dried
- customevaporated
출처 및 근거
- ORD 기록
- ord-b356e4fd8c3748c0b1563e95a535d43a
- 출처 데이터셋
- uspto-grants-2014_08
- 특허 번호
- US08796467B2
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