Hydrochloric Acid → N-{2-Amino-2-[3-(trifluoromethyl)phenyl]ethyl}formamide hydrochloride
반응식
[CH:1]([NH:3][CH2:4][CH:5]([NH:16]C(=O)OC(C)(C)C)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1)=[O:2].[ClH:24]>ClCCl.O1CCOCC1>[ClH:24].[NH2:16][CH:5]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:13])([F:14])[F:15])[CH:7]=1)[CH2:4][NH:3][CH:1]=[O:2]참가 물질
5
실험 절차
Of the compound from Example 23A, 66 mg (0.2 mmol) were introduced in 1.5 ml of dichloromethane and admixed at RT with 1.56 ml of a 4N solution of hydrogen chloride in dioxane. The reaction mixture was stirred at RT for 1 h. The reaction mixture was freed from the volatile components on a rotary evaporator and dried in an HV. This gave 50 mg (94% of theory) of the title compound.
후처리
- customThe reaction mixture was freed from the volatile components on a rotary evaporator
- customdried in an HV
출처 및 근거
- ORD 기록
- ord-5a2aa4d682614b718ce6cc6e502222d3
- 출처 데이터셋
- uspto-grants-2014_08
- 특허 번호
- US08796324B2
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