Triphenylphosphine → HCID 59536867, 화합물

HRID 2402792노트

반응식

HRID 2402792 반응식
[CH3:1][S:2]([CH2:4][CH:5]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]([F:15])([F:14])[F:13])=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>ClC(Cl)(Cl)Cl>[CH3:1][S:2][CH2:4][CH:5]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]([F:15])([F:14])[F:13]

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 59536884tert-Butyl {2-(methylsulphinyl)-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate

생성물 1

HCID 59536867HCID 59536867, 화합물

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

Of the compound from Example 108A, 400 mg (1.14 mmol), and 567 mg (2.16 mmol) of triphenylphosphine, were dissolved in 14 ml of tetrachloromethane. The reaction mixture was stirred overnight at reflux temperature and then freed from the solvent on a rotary evaporator. The residue was purified by preparative HPLC [Method 20]. The product fraction was freed from the solvent on a rotary evaporator. Drying in an HV gave 340 mg (85% of theory) of the title compound.

후처리

  1. temperatureat reflux temperature
  2. customfreed from the solvent on a rotary evaporator
  3. customThe residue was purified by preparative HPLC [Method 20]
  4. customThe product fraction was freed from the solvent on a rotary evaporator
  5. customDrying in an HV

출처 및 근거

ORD 기록
ord-4eb2127b3e0b46f28ba85d27af438664
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08796324B2

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