Methanol → 3-methoxy-9-oxo-9H-indeno[1,2-b]pyrazine-2-carbonitrile

HRID 240306

반응식

HRID 240306 반응식
[O:1]=[C:2]1[C:14]2[C:9](=[N:10][C:11](C#N)=[C:12]([C:15]#[N:16])[N:13]=2)[C:8]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]1=2.[CH3:19][OH:20]>>[CH3:19][O:20][C:11]1[N:10]=[C:9]2[C:8]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[C:2](=[O:1])[C:14]2=[N:13][C:12]=1[C:15]#[N:16]

참가 물질

3

반응물 2

HCID 887MethanolHCID 2929299-oxo-9H-indeno(1,2-b)pyrazine-2,3-dicarbonitrile

생성물 1

HCID 160653533-methoxy-9-oxo-9H-indeno[1,2-b]pyrazine-2-carbonitrile수율 126.5%

실험 절차

To a suspension of 1 (1.10 g, 4.7 mmol) in MeOH (47 ml) sodium (110 mg) was added and the mixture was stirred at room temperature for 16 hours. The precipitate was filtered, washed with EtOH and dried under vacuum, yielding 3 (1.03 g, 93%) as yellow-green solid.

후처리

  1. additionwas added
  2. filtrationThe precipitate was filtered
  3. washwashed with EtOH
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-b40012b19977406f87d5a10b4b6e4989
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648076B2

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