Sodium Sulfate → HCID 16065357, 화합물

HRID 240308

반응식

HRID 240308 반응식
[O:1]=[C:2]1[C:14]2[C:9](=[N:10][C:11](C#N)=[C:12]([C:15]#[N:16])[N:13]=2)[C:8]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]1=2.C([O-])(=O)C.[NH4+:23].[O-]S([O-])(=O)=O.[Na+].[Na+]>C1COCC1>[NH2:23][C:11]1[N:10]=[C:9]2[C:8]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[C:2](=[O:1])[C:14]2=[N:13][C:12]=1[C:15]#[N:16]

참가 물질

5

반응물 3

HCID 24436Sodium SulfateHCID 2929299-oxo-9H-indeno(1,2-b)pyrazine-2,3-dicarbonitrileHCID 517165Ammonium Acetate

생성물 1

HCID 16065357HCID 16065357, 화합물수율 90%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
70 °C

실험 절차

A mixture of 1 (201 mg, 0.86 mmol), ammonium acetate (331 mg, 4.3 mmol) and Na2SO4 (200 mg) in THF (2.9 ml) was stirred at 70° C. in sealed tube for 18 hours. The solvent was evaporated, water (5 ml) was added and the precipitate filtered, washed with water and dried under vacuum, affording 7 (171 mg, 90%) as green solid.

후처리

  1. customThe solvent was evaporated
  2. additionwater (5 ml) was added
  3. filtrationthe precipitate filtered
  4. washwashed with water
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-cbcbdab1543444ab9d69875510961707
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648076B2

연결된 노트

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