Lithium hydroxide, monohydrate → Lithium 1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)azetidine-2-carboxylate

반응식

[F:1][C:2]([F:19])([F:18])[CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([N:10]2[CH2:13][CH2:12][CH:11]2[C:14]([O:16]C)=[O:15])[CH2:6][CH2:5]1.O.[OH-].[Li+:22]>>[F:19][C:2]([F:1])([F:18])[CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([N:10]2[CH2:13][CH2:12][CH:11]2[C:14]([O-:16])=[O:15])[CH2:6][CH2:5]1.[Li+:22]

참가 물질

반응물 2

HCID 168937Lithium hydroxide, monohydrate

HCID 86692753Methyl 1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)azetidine-2-carboxylate

생성물 1

HCID 86692769Lithium 1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)azetidine-2-carboxylate

실험 절차

The reaction of methyl 1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)azetidine-2-carboxylate 19G and lithium hydroxide monohydrate yielded lithium 1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)azetidine-2-carboxylate as a light brown solid (quant.). MS ISP (m/e): 267.2 (100) [(M+H)]+.

출처 및 근거

ORD 기록: ord-f80954a47015488ca38d4f743f29a0e7
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08802665B2

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