Hydrochloric Acid → 3-Oxo-4-phenyl-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylic acid

HRID 240340노트

반응식

HRID 240340 반응식
[O:1]=[C:2]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:6]2[N:14]=[CH:15][CH:16]=[CH:17][C:5]=2[N:4]=[C:3]1[C:18]([O:20]CC)=[O:19].Cl>C(O)(=O)C>[O:1]=[C:2]1[N:7]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:6]2[N:14]=[CH:15][CH:16]=[CH:17][C:5]=2[N:4]=[C:3]1[C:18]([OH:20])=[O:19]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68476438HCID 68476438, 화합물

생성물 1

HCID 675319973-Oxo-4-phenyl-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylic acid수율 67.6%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

10.74 g (36 mmol) of ethyl 3-oxo-4-phenyl-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylate was dissolved in acetic acid (270 mL), and 6N hydrochloric acid (80 mL) was added thereto at room temperature. Then, the mixture was stirred overnight at room temperature. After confirming the completion of the reaction, the solvent was distilled off under reduced pressure, and water (100 mL) was added. The solid thus obtained was separated by filtration and dried, to obtain 6.50 g (yield: 67%) of 3-oxo-4-phenyl-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylic acid as pale brown crystals.

후처리

  1. customat room temperature
  2. customthe completion of the reaction
  3. distillationthe solvent was distilled off under reduced pressure, and water (100 mL)
  4. additionwas added
  5. customThe solid thus obtained
  6. customwas separated by filtration
  7. customdried

출처 및 근거

ORD 기록
ord-13c88de8ddd8457394f3b25c19085c72
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648075B2

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