Water → 5-methyl-3-(pyridin-4-yl)-1H-pyrazole-4-carboxylic acid
반응식
[CH3:1][C:2]1[NH:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]([O:15]CC)=[O:14].[OH-].[Na+].O>C(O)C>[CH3:1][C:2]1[NH:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][N:10]=[CH:11][CH:12]=2)[C:3]=1[C:13]([OH:15])=[O:14]참가 물질
5
실험 절차
To a solution of ethyl 5-methyl-3-(pyridin-4-yl)-1H-pyrazole-4-carboxylate (3.1 g) in ethanol (20 mL) were added sodium hydroxide (8.0 g) and water (10 mL), and the mixture was heated under reflux overnight. The solvent was evaporated under reduced pressure, the pH of the mixture was adjusted to 5 with 2 N hydrochloric acid, and mixture was concentrated under reduced pressure. The obtained solid was collected by filtration and washed with water to give the title compound (2.4 g).
후처리
- temperaturethe mixture was heated
- temperatureunder reflux overnight
- customThe solvent was evaporated under reduced pressure
- concentrationwas concentrated under reduced pressure
- filtrationThe obtained solid was collected by filtration
- washwashed with water
출처 및 근거
- ORD 기록
- ord-78fd8fbccd1042d6922d5ad87cb9fb49
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08648079B2
반응 노트
불러오는 중…