Oxygen → 6-Bromo-2-(4-tert-butyl-cyclohexyloxy)-quinoline
반응식
[C:1]([C@H:5]1[CH2:10][CH2:9][C@H:8](OC2C=C3C(=CC=2)N=C(C)C=C3C(F)(F)F)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[Br:27][C:28]1[CH:29]=[C:30]2[C:35](=[CH:36][CH:37]=1)[N:34]=[C:33]([OH:38])[CH:32]=[CH:31]2.O=O>>[Br:27][C:28]1[CH:29]=[C:30]2[C:35](=[CH:36][CH:37]=1)[N:34]=[C:33]([O:38][CH:8]1[CH2:9][CH2:10][CH:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:6][CH2:7]1)[CH:32]=[CH:31]2참가 물질
4
실험 절차
Synthesized as per 6-(trans-4-tert-Butyl-cyclohexyloxy)-2-methyl-4-trifluoromethyl-quinoline using 6-Bromo-quinolin-2-ol as starting material. Alkylation was confirmed to be on the oxygen by 2D NMR(HMQC) of the subsequent intermediate. ESI-MS (M+H+): 362.1/364.10).
출처 및 근거
- ORD 기록
- ord-a43487738b284812937d96c687f5a31e
- 출처 데이터셋
- uspto-grants-2014_08