4-Nitro-1H-indole → 4-Aminoindole

HRID 240468

반응식

HRID 240468 반응식
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]=[CH:7][NH:8]2)([O-])=O.[H][H]>[Pd].C1COCC1>[NH2:1][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]=[CH:7][NH:8]2

참가 물질

5

반응물 2

HCID 1457664-Nitro-1H-indoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 5834314-Aminoindole

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

A round-bottom flask was charged with 4-nitroindole (4.8 g, 30 mmol), Palladium on carbon (10%, 480 mg), and THF (50 mL), and the mixture was stirred under one hydrogen atmosphere overnight. TLC showed the reaction was complete. The catalyst was filtered off and the filtrate was concentrated to afford 4-amino-1H-indole, which was used directly in the next step without purification.

후처리

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-c9141032da62429ea72e176f8ff59e25
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648086B2

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