Sodium Hydroxide → HCID 71087699, 화합물

HRID 2405082노트

반응식

HRID 2405082 반응식
[CH2:1]([N:3]1[C:11]2[CH:10]=[C:9]([C:12]([O:14]C)=[O:13])[N:8]=[CH:7][C:6]=2[C:5]([CH3:16])=[CH:4]1)[CH3:2].[OH-].[Na+]>C1COCC1>[CH2:1]([N:3]1[C:11]2[CH:10]=[C:9]([C:12]([OH:14])=[O:13])[N:8]=[CH:7][C:6]=2[C:5]([CH3:16])=[CH:4]1)[CH3:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 71087757HCID 71087757, 화합물

생성물 1

HCID 71087699HCID 71087699, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In a 200-ml round bottom flask, methyl 1-ethyl-3-methyl-1H-pyrrolo[3,2-c]pyridine-6-carboxylate (1N, 6.0 g, 28 mmol) was dissolved in THF (50 ml). To the mixture was added a 2M NaOH (28 ml, 55 mmol) solution. The reaction was stirred at room temperature for 3 hrs. After completion, volatiles were removed and the residue was cooled in an ice bath and neutralized with dilute HCl to pH=4.0-4.5. The aqueous mixture washed with ethyl acetate (2×100 ml) and then lyophilized to give the crude product 1-ethyl-3-methyl-1H-pyrrolo[3,2-c]pyridine-6-carboxylic acid (1O) which is used in the next step without further purification.

후처리

  1. customAfter completion, volatiles were removed
  2. temperaturethe residue was cooled in an ice bath
  3. washThe aqueous mixture washed with ethyl acetate (2×100 ml)

출처 및 근거

ORD 기록
ord-cd24699dac754b34880ab939ae009daf
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08802695B2

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