Hydrochloric Acid → 3-Methyl-4-((1-methyl-1H-benzimidazol-5-yl)oxy)benzenamine

HRID 240560노트

반응식

HRID 240560 반응식
Cl.[CH3:2][C:3]1[CH:4]=[C:5]([NH:20]C=O)[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[CH:19]=[CH:18][C:13]2[N:14]([CH3:17])[CH:15]=[N:16][C:12]=2[CH:11]=1.C(=O)(O)[O-].[Na+]>CO.O>[CH3:2][C:3]1[CH:4]=[C:5]([NH2:20])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[CH:19]=[CH:18][C:13]2[N:14]([CH3:17])[CH:15]=[N:16][C:12]=2[CH:11]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 86650897N-(3-methyl-4-(1-methyl-1H-benzo[d]imidazol-5-yloxy)phenyl)formamide

생성물 1

HCID 669369553-Methyl-4-((1-methyl-1H-benzimidazol-5-yl)oxy)benzenamine

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of concentrated aqueous HCl (10 mL) in methanol (10 mL) was added N-(3-methyl-4-(1-methyl-1H-benzo[d]imidazol-5-yloxy)phenyl)formamide (1.70 g, 6.04 mmol). After heating to reflux for 2 hours, the reaction mixture was cooled to room temperature and diluted with water (100 mL). The mixture was neutralized with sodium bicarbonate and extracted with dichloromethane. The organic solution was dried over Na2SO4, filtered and concentrated under reduced pressure to provide the product.

후처리

  1. temperatureAfter heating
  2. temperatureto reflux for 2 hours
  3. extractionextracted with dichloromethane
  4. dry with materialThe organic solution was dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure
  7. customto provide the product

출처 및 근거

ORD 기록
ord-4439c8b887064b17aa1a606901c67f91
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648087B2

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