2-Amino-5-nitrobenzoic acid → HCID 178526470, 화합물

HRID 240566

반응식

HRID 240566 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.C(O)(=O)C.[CH:18](N)=[NH:19]>COC(O)C>[N+:11]([C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[CH:18][N:19]=[C:4]2[OH:6])([O-:13])=[O:12]

참가 물질

4

반응물 2

HCID 120322-Amino-5-nitrobenzoic acidHCID 160693Formamidine acetate

생성물 1

HCID 178526470HCID 178526470, 화합물

시약·촉매·용매 1

HCID 30156371-Methoxyethanol용매

반응 조건

온도
115 °C

실험 절차

A mixture of 2-amino-5-nitrobenzoic acid (1000 g, 5 mol) and formamidine acetate (1000 g, 10 mol) were dissolved in methoxyethanol (4 L) and heated to 115° C. for 16 hours. After cooling the mixture to room temperature, ice water (5 L) was added and the mixture was stirred for 30 minutes before collecting the product (125 g, 14%) by filtration.

후처리

  1. temperatureAfter cooling the mixture to room temperature
  2. custombefore collecting the product (125 g, 14%)
  3. filtrationby filtration

출처 및 근거

ORD 기록
ord-c6eaa425e0df4e24ab878d970d8aa4c3
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648087B2

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