Formamide → HCID 178518013, 화합물

HRID 240571

반응식

HRID 240571 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:12]([NH2:14])=O>O>[I:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[CH:12][N:14]=[C:4]2[OH:5]

참가 물질

4

반응물 2

HCID 713FormamideHCID 72911Benzoic acid, 2-amino-5-iodo-

생성물 1

HCID 178518013HCID 178518013, 화합물수율 83%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
190 °C

실험 절차

A mixture of 2-amino-5-iodobenzoic acid (125 g, 475 mmol) and formamide (200 mL) was heated to 190° C. for 2 hours. After cooling to room temperature, the reaction mixture was poured into water (500 mL) and stirred for 2 hours. The solids were filtered and dried under high vacuum to provide the product (108 g, 83%).

후처리

  1. temperatureAfter cooling to room temperature
  2. filtrationThe solids were filtered
  3. customdried under high vacuum

출처 및 근거

ORD 기록
ord-1cf203d6a8f34d2ea4d9ba40e1884b22
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648087B2

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