Hydrochloric Acid → 4-[(4-Chlorophenyl)methyl]-4-piperidinemethanamine
반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)([C:14]#[N:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CO.O1CCOCC1>[Cl:23][C:20]1[CH:21]=[CH:22][C:17]([CH2:16][C:11]2([CH2:14][NH2:15])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:18][CH:19]=1참가 물질
5
실험 절차
To a solution of 4-(4-chlorobenzyl)-4-cyanopiperidine-1-carboxylic acid tert-butyl ester (0.500 g, 1.493 mmol) in methanol (3 ml) was added 4M HCl in dioxane (10 ml). After stirring for 19 hours, the solution was concentrated to give the deprotected amine as the hydrochloride salt (0.405 g).
후처리
- concentrationthe solution was concentrated
출처 및 근거
- ORD 기록
- ord-6b9e7cd97d9f45f3a4633b664eb91d39
- 출처 데이터셋
- uspto-grants-2014_08
- 특허 번호
- US08809336B2
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