Ammonium formate → (S)-1-(3-(2-amino-5-methylphenoxy)piperidin-1-yl)-2,2,2-trifluoroethanone

HRID 240601노트

반응식

HRID 240601 반응식
C([O-])=O.[NH4+].[F:5][C:6]([F:27])([F:26])[C:7]([N:9]1[CH2:14][CH2:13][CH2:12][C@H:11]([O:15][C:16]2[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=2[N+:23]([O-])=O)[CH2:10]1)=[O:8]>[Pd].CO>[NH2:23][C:17]1[CH:18]=[CH:19][C:20]([CH3:22])=[CH:21][C:16]=1[O:15][C@H:11]1[CH2:12][CH2:13][CH2:14][N:9]([C:7](=[O:8])[C:6]([F:27])([F:5])[F:26])[CH2:10]1

참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 58413139(S)-2,2,2-trifluoro-1-(3-(5-methyl-2-nitrophenoxy)piperidin-1-yl)ethanone

생성물 1

HCID 58413119(S)-1-(3-(2-amino-5-methylphenoxy)piperidin-1-yl)-2,2,2-trifluoroethanone

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Amoniumformiate (0.238 g) was added into a suspension of (S)-2,2,2-trifluoro-1-(3-(5-methyl-2-nitrophenoxy)piperidin-1-yl)ethanone and palladium on charcoal (50.0 mg) in MeOH (6.0 ml) at room temperature. The mixture was heated at reflux for 40 mins. The mixture was filtered through a pad of celite and the filtercake was washed with dichloromethane. The filtrate was washed with water and. The residue was purfied by chromatography.

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 40 mins
  3. filtrationThe mixture was filtered through a pad of celite
  4. washthe filtercake was washed with dichloromethane
  5. washThe filtrate was washed with water

출처 및 근거

ORD 기록
ord-300843a7813441c6b1ca2abcb34f42f2
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648068B2

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