Hydrochloric Acid → Amiselimod(MT-1303) hydrochloride

HRID 2406023노트

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HRID 2406023 반응식
C(OC(=O)[NH:7][C:8]1([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[C:20]([C:32]([F:35])([F:34])[F:33])[CH:19]=2)[CH2:13][O:12]C(C)(C)[O:10][CH2:9]1)(C)(C)C.[ClH:37]>C(O)C>[ClH:37].[NH2:7][C:8]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[C:20]([C:32]([F:33])([F:34])[F:35])[CH:19]=1)([CH2:9][OH:10])[CH2:13][OH:12]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57704611HCID 57704611, 화합물

생성물 1

HCID 67418070Amiselimod(MT-1303) hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
80 °C

실험 절차

Compound 1-2 (640 mg) was dissolved in ethanol (15 ml), concentrated hydrochloric acid (3 ml) was added, and the mixture was stirred at 80° C. for 2 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (492 mg) as white powder.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. washthe residue was washed with diethyl ether

출처 및 근거

ORD 기록
ord-577b6134ed3a46919e97c51dd84d2667
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08809304B2

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