To a solution of 4-[4-Fluoro-2-((S)-1-methanesulfonyl-piperidin-3-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (120 mg) at 0° C. was added DIPEA (49 μl) followed by HATU (104 mg) and the solution was stirred for 30 min. A solution of ammonia in methanol (7M; 0.3 ml) was added and the solution allowed to warm to room temperature and stirred for 1 h. The solvent was evaporated and traces of DMF removed by co-evaporation with toluene. The residue was triturated with MeOH and the solid collected by filtration to give the desired product.
