Indole → 1-Hexyl-1H-indole

HRID 2406632노트

반응식

HRID 2406632 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[OH-].[K+].Br[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[Cl-].[NH4+]>CS(C)=O.C(OCC)(=O)C>[CH2:13]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1)[CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

참가 물질

7

반응물 4

HCID 798IndoleHCID 81011-BromohexaneHCID 14797Potassium HydroxideHCID 25517Ammonium Chloride

생성물 1

HCID 127154041-Hexyl-1H-indole

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 1H-indole in DMSO was added KOH at RT and was stirred for 30 minutes. Then to this mixture, 1-bromo-hexane was added and stirred for 3 hours. The reaction was treated with saturated ammonium chloride and ethyl acetate. The product was purified by column chromatography.

후처리

  1. stirringstirred for 3 hours
  2. customThe product was purified by column chromatography

출처 및 근거

ORD 기록
ord-e2f4ee4111df4e23822596d001102ed1
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08809382B2

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