Lithium hydroxide, monohydrate → (3R)-5-(5-chloro-2-hexyl-1-methylindol-3-yl)-3-methyl-5-oxopentanoic acid

HRID 2406653노트

반응식

HRID 2406653 반응식
C[O:2][C:3](=[O:27])[CH2:4][C@H:5]([CH3:26])[CH2:6][C:7]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([Cl:18])[CH:16]=2)[N:11]([CH3:19])[C:10]=1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[O:8].O.[OH-].[Li+]>C(O)(C)C.O>[Cl:18][C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[N:11]([CH3:19])[C:10]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[C:9]2[C:7](=[O:8])[CH2:6][C@@H:5]([CH3:26])[CH2:4][C:3]([OH:27])=[O:2]

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 66644148Methyl 5-(5-chloro-2-hexyl-1-methyl-1H-indol-3-yl)-3-(R)-methyl-5-oxopentanoate

생성물 1

HCID 49802026(3R)-5-(5-chloro-2-hexyl-1-methylindol-3-yl)-3-methyl-5-oxopentanoic acid

시약·촉매·용매 2

HCID 962Water용매HCID 3776Isopropanol용매

실험 절차

To the solution of Methyl-5-(5-chloro-2-hexyl-1-methyl-1H-indol-3-yl)-3-(R)-methyl-5-oxopentanoate in iso-propanol and water was added lithium hydroxide monohydrate and was stirred at RT for three hours. The product was purified by column chromatography.

후처리

  1. customThe product was purified by column chromatography

출처 및 근거

ORD 기록
ord-e9ab8f561224433e8a012cb380e93e48
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08809382B2

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