Lithium hydroxide, monohydrate → (3R)-5-(5-chloro-2-hexyl-1-methylindol-3-yl)-3-methyl-5-oxopentanoic acid

HRID 2406659노트

반응식

HRID 2406659 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[C:5]2[C:18](=[O:27])[CH2:19][C@@H:20]([CH3:26])[CH2:21][C:22]([O:24]C)=[O:23].O.[OH-].[Li+]>C(O)(C)C.O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[C:5]2[C:18](=[O:27])[CH2:19][C@@H:20]([CH3:26])[CH2:21][C:22]([OH:24])=[O:23]

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 66644148Methyl 5-(5-chloro-2-hexyl-1-methyl-1H-indol-3-yl)-3-(R)-methyl-5-oxopentanoate

생성물 1

HCID 49802026(3R)-5-(5-chloro-2-hexyl-1-methylindol-3-yl)-3-methyl-5-oxopentanoic acid

시약·촉매·용매 2

HCID 962Water용매HCID 3776Isopropanol용매

실험 절차

To the solution of Methyl 5-(5-chloro-2-hexyl-1-methyl-1H-indol-3-yl)-3-(R)-methyl-5-oxopentanoate in iso-propanol and water was added lithium hydroxide monohydrate and was stirred at RT for three hours. The product was purified by column chromatography.

후처리

  1. customThe product was purified by column chromatography

출처 및 근거

ORD 기록
ord-d5da485483a64fdb81de973b4ce0f4a5
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08809382B2

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