Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphonium, hexyltriphenyl-, bromide (1:1) → 5-Chloro-2-hept-1-enyl-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphonium, hexyltriphenyl-, bromide (1:1) | HCID 2724569 | — |
| 반응물 | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| 반응물 | 5-Chloro-1H-indole-2-carbaldehyde | HCID 12203318 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-Chloro-2-hept-1-enyl-1H-indole | HCID 68748882 | — |
반응 단계
To the cold suspension of hexyl-triphenyl-phosphonium bromide in THF was added LiHMDS in THF and the mixture was stirred for 30 minutes and then the solution of 5-chloro-1H-indole-2-carbaldehyde was added to the reaction mixture and stirred for 3 hours. The reaction was quenched with saturated ammonium chloride solution and extracted with ethyl acetate. The product, 5-chloro-2-hept-1-enyl-1H-indole was purified by column chromatography.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08809382B2 |
| 출처 데이터셋 | uspto-grants-2014_08 |
| ORD ID | ord-6ba67f2cc1b5452ca7cc6b6309b94b4b |
| 출처 메모 | uspto-grants-2014_08 |