1-Aminopiperidin-4-OL → 5-Cyclohexyl-N-(4-hydroxypiperidin-1-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

HRID 240699

반응식

HRID 240699 반응식
[CH:1]1([C:7]2[CH:8]=[C:9]([C:19]([OH:21])=O)[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:22][N:23]1[CH2:28][CH2:27][CH:26]([OH:29])[CH2:25][CH2:24]1>>[CH:1]1([C:7]2[CH:8]=[C:9]([C:19]([NH:22][N:23]3[CH2:28][CH2:27][CH:26]([OH:29])[CH2:25][CH2:24]3)=[O:21])[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:16])([F:18])[F:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

3

반응물 2

HCID 121256451-Aminopiperidin-4-OLHCID 712939525-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

생성물 1

HCID 712940895-Cyclohexyl-N-(4-hydroxypiperidin-1-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

실험 절차

The title compound was synthesized in analogy to Example 1 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxylic acid and 1-amino-4-piperidinol (CAN 79414-82-7) as starting materials; LC-MS (UV peak area/ESI) 96.4%, 402.1991 (M+H)+.

출처 및 근거

ORD 기록
ord-2eeb7b93cccc47458664bd6c7721f77c
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648099B2

연결된 노트

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