Sodium Hydroxide → 2,3-dihydro-2,2-diMethylbenzofuran-5-carboxylic acid

HRID 2407474노트

반응식

HRID 2407474 반응식
[OH-].[Na+].C([O:5][C:6]([C:8]1[CH:9]=[CH:10][C:11]2[O:15][C:14]([CH3:17])([CH3:16])[CH2:13][C:12]=2[CH:18]=1)=[O:7])C>>[CH3:16][C:14]1([CH3:17])[CH2:13][C:12]2[CH:18]=[C:8]([C:6]([OH:7])=[O:5])[CH:9]=[CH:10][C:11]=2[O:15]1

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 59509487HCID 59509487, 화합물

생성물 1

HCID 148382312,3-dihydro-2,2-diMethylbenzofuran-5-carboxylic acid

반응 조건

온도
75 °C

실험 절차

An aqueous solution (10 mL) of sodium hydroxide (0.78 g, 0.0195 mol) is added to an ethanolic solution (30 mL) of 2,2-dimethyl-2,3-dihydrobenzofuran-5-carboxylic acid ethyl ester (3.9 g, 0.018 mol). The reaction mixture is heated at 75° C. for four and an half hours. Ethanol is removed under reduced pressure. Demineralized water is added to the residue and pH is brought to ˜3 with 1 N HCl. Solid thus obtained is filtered, washed with demineralized water and dried under reduced pressure to give 2,2-dimethyl-2,3-dihydrobenzofuran-5-carboxylic acid.

후처리

  1. customEthanol is removed under reduced pressure
  2. additionDemineralized water is added to the residue and pH
  3. customSolid thus obtained
  4. filtrationis filtered
  5. washwashed with demineralized water
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-a00a28ebb39b4582afdeb63a8db86b20
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08809539B2

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